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Finally, S56 indicated that "Sometimes, simply the diagram with out a short contextual clarification made the exercise tougher to know than fixing it.". While extra research is necessary on the topic, the correlation found between people with sickle cell trait and an increased danger of sudden death appears to be associated to microcirculatory disorders, during exercise. Sickle-cell disease and the related trait are most prevalent in Africa and Central America, which is attributed to natural selection: the sickle-cell trait confers a survival advantage in areas with a high occurrence of malaria, which has a high death charge among people without the trait. The significance of the sickle-cell trait is that it does not show any symptoms, nor does it trigger any main difference in blood cell count. Renal medullary carcinoma, a cancer affecting the kidney, is a very uncommon complication seen in patients with sickle cell trait. PET scans in kids with the trait.
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